It is well recognized that spirometry does not capture small airway disease. The lengthy duration of spirometry testing time along with the challenge of obtaining high-quality measurements in the elderly and children also pose major limitations.
Oscillometry via forced oscillation technique (FOT) is an emerging endpoint in respiratory clinical trials, particularly in asthma and COPD. Used in combination with FEV1 and other endpoints, FOT is especially useful for indications that impact the small airways of the lungs where changes can be detected earlier when compared to spirometry or imaging.
In this webinar Dr. Brian Lipworth, Head of the Scottish Centre for Respiratory Research, will discuss:
- Oscillometry methods and a comparison of impulse vs airwave oscillometry (IOS vs. AOS)
- How oscillometry is conducted, what is measured, and what this means for patients in clinical research
- Trade-offs between oscillometry and spirometry
- Potential application of FOT/AOS in particular indications